苏自奋的个人简介
苏自奋,男, 1958 年 12 月生,研究员,研究方向为同位素及辐射生物医学技术研究
个人简介
苏自奋 研究员,男 1958 年 12 月生
研究方向:同位素及辐射生物医学技术研究
工作单位:四川大学原子核科学与技术研究所
研究员。1988 年 3 月年从中科院化学所分析化学专业研究生毕业并获得博士学位。1989 年德国洪堡学者。从 1989 年起从事放射药物开发及研究,先后在德国、加拿大、美国的国际知名科研单位与众多的化学家、药物学家、药剂师、肿瘤科专家、以及核医学科专家共同工作过。
研究领域
肿瘤特异性藕联药物的开发研究 ;
特异性多肽抗癌药物的开发研究 ;
疾病的分子显像研究;
新型高性能乏氧肿瘤细胞显像剂及放射药物的研究开发
新型高灵敏高特异性肿瘤新生血管显像剂及放射药物的研究开发;
结合中药研究提高抗癌药物效果的基础及应用问题;
结合分子显像技术研究具有优越抗癌效果的中草药、合成药、生化药以及相关基础问题的研究;
脑瘤放射药物的研究开发。
发表文章选录
⒈ Zi-Fen Su,Jiang He,Mary Rusckowski,and Donald J. Hnatowich. (2003) In Vitro Cell Studies of Technetium -99m labelled RGD-HYNIC Peptide,a comparison of Tricine and EDDA as Co-ligands. Nucl. Med. Biol. 30,141-9.
⒉ Zi-Fen Su,Guozheng Liu,Suresh Gupta,Zhihong Zhu,Mary Rusckowski and Donald J. Hnatowich (2002) In Vitro and In Vivo Evaluations of a Technetium -99m Labeled Cyclic RGD Peptide as a Specific Marker of a V b 3 Integrin for Tumor Imaging. Bioconjug. Chem .,13,561-70.
⒊ Zi-Fen Su,James R. Ballinger,A. M. Rauth,Douglas N. Abrams,and Mervyn W. Billinghurst. (2000) A Novel Amine-dioxime Chelator for Technetium -99m : Synthesis and Evaluation of 2-Nitroimidazole-containing Analogs as Markers for Hypoxic Cells. Bioconjugate Chemistry,11,652-63.
⒋ Zi-Fen Su,Xiuguo Zhang,James R. Ballinger,A. M. Rauth,Alfred Pollak,and John R. Thornback. (1999) Synthesis and Evaluation of Two Technetium-99mTc-Labeled Peptidic 2-Nitroimidazoles for Imaging Hypoxia. Bioconjugate Chemistry,10,897-904.
⒌ Wang J,Chen P,Su ZF,Vallis K,Sandhu J,Cameron R,Hendler A,Reilly RM.(2001) Amplified delivery of indium-111 to EGFR-positive human breast cancer cells. Nucl Med Biol . 28 ⑻:895-902.
⒍ Li YQ,Ballinger JR,Nordal RA,Su ZF,Wong CS. (2001) Hypoxia in radiation-induced blood-spinal cord barrier breakdown. Cancer Res. 61,3348-54.
⒎ Xiuguo Zhang,Zi-Fen Su,James R. Ballinger,A. M. Rauth,Alfred Pollak,and John R. Thornback,Targeting Hypoxia in Tumors Using 2-Nitroimidazole with Peptidic Chelator for Technetium -99m : Effect of Lipophilicity. Bioconjugate Chemistry,11,401-7.
⒏ K Utsunomiya,J R Ballinger,X. Zhang,Z-F Su,T Tsuchida,and M Ichise. (1999) Comparison Of The Kinetics Of 99m Tc-Sestamibi and 99m Tc-Tetrofosmin In A Multidrug-Resistant Tumour Cell Line. Eur. J. Nucl. Med . 26 ⑼,1047
⒐ K. Schwochau,K.H. Linse and Z.F. Su. (1992) Synthesis,Characterization and Biodistribution of the Cationic Technetium(I)-1,10-Phenanthroline Chelate.,Appl. Radiat. Isotope,43⑼,1079-82.
⒑ Z.F. Su,K.H. Linse,H.J. Steinmetz and K. Schwochau. (1992) Preparation and Evaluation of Cationic 99 Tc/ 99m Tc Dimethoxy- and Diethoxyl-Hexanedione Dioxime Complexes. J. Labelled Comp. Radiopharm.,XXⅪ⑴,61-70.