钱其军

时间：2023-12-12 03:56:20编辑：小简

钱其军的个人简介

钱其军，男，1964年9月出生，浙江嵊州人。医学博士，教授，博士研究生导师。现任上海大学医学院副院长，上海大学细胞治疗创新研究院院长，上海细胞治疗研究院院长，上海细胞治疗工程技术研究中心主任，上海吴孟超联合诺贝尔奖获得者医疗科技创新中心主任，上海细胞治疗集团董事长兼总裁。

国家杰出青年科学基金获得者，国家重点研发计划项目精准医疗专项首席科学家，上海市优秀学科带头人，上海市领军人才，上海市“五一劳动奖章”获得者。现任中国生物医药技术协会精准医疗分会、中国医药质量管理协会细胞治疗质量控制与研究专业委员会等8个行业学会的副主任委员。

个人经历

现任上海大学医学院副院长，上海大学细胞治疗创新研究院院长，上海细胞治疗研究院院长，上海细胞治疗工程技术研究中心主任，上海吴孟超联合诺贝尔奖获得者医疗科技创新中心主任，上海细胞治疗集团董事长兼总裁。

先后主持承担国家科技重大专项、863项目、国自然杰青、海外杰青、重大项目、重点项目、面上项目等国家级课题16项。获国家科学技术进步创新团队奖1项，省部级二等奖4项，三等奖3项。共发表SCI论文83篇；已申请217项细胞治疗相关专利,获专利授权47项，其中美国发明专利2 项。

主要从事肿瘤精准细胞免疫治疗，包括：精准细胞免疫治疗临床应用、精准细胞免疫治疗新技术研发、精准免疫细胞储存、基因检测、精准细胞临床级规模制备及相关设备的研发。目前团队正在研发细胞玄铁剑：采用非病毒载体进行基因修饰的新一代CAR-T；细胞六脉神剑：PNA-T精准杀灭癌细胞；细胞倚天剑：PIK-T，通过表达免疫检查点抗体如抗PD-1抗体来改变癌症微环境，解除对免疫细胞的抑制，通过非病毒载体、纳米抗体及mRNA技术来实现三剑合一的白泽剑技术及超级白泽T细胞。2019年4月申报项目以CD19为靶点的CAR-T细胞治疗新药获得国家药监局许可开展临床实验，是目前国内第一家通过许可的以非病毒载体制备的CAR-T细胞治疗产品进入临床。

为最早提出肿瘤基因－病毒治疗新策略研究者之一，该策略结合了传统的肿瘤基因治疗与病毒治疗的双重优势，体内外实验证明该策略的疗效明显优于单一的基因治疗与病毒治疗，在此基础上研发了一种腺病毒生产纯化平台，为国内上百家单位提供腺病毒技术支持。最早成功利用腺病毒载体系统高效表达全长抗体，在国际首次提出全长抗体基因治疗策略。

代表著作

1、癌症战争之克癌新道 2020-03 中国科学技术出版社

2、癌症战争 2014-10 中国科学技术出版社

3、Therapeutic Cancer Vaccines

主要奖励

1.新的癌症靶向基因-病毒治疗（CTGVT）2013年获上海市科学技术奖二等奖刘新垣　钱其军　吴孟超　顾锦法　钱　程

2.第二军医大学肝癌临床与基础集成化研究创新团队2012年国家科学技术进步奖

3.携带治疗基因的特异性增殖型腺病毒在肝癌中的实验性研究广州军区广州总医院上海东方肝胆外科医院2011年广东省科学技术进步三等奖彭林辉、钱其军、苏长青、张琪、詹世林、石英、陈建雄

4.肿瘤基因-病毒治疗中国人民解放军第二军医大学第三附属医院中国科学院上海生命科学院生化与细胞研究所、浙江理工大学2005年上海市科学技术进步二等奖钱其军、刘新垣、吴孟超、张琪、顾锦法

5.肿瘤靶向基因-病毒治疗中国人民解放军第二军医大学第三附属医院中国科学院上海生命科学院生化与细胞研究所、浙江理工大学2005年上海市医学奖二等奖钱其军、刘新垣、吴孟超、张琪、顾锦法

6.肿瘤靶向基因-病毒治疗中国人民解放军第二军医大学第三附属医院中国科学院上海生命科学院生化与细胞研究所、浙江理工大学2005年中华医学科技奖三等奖钱其军、刘新垣、吴孟超、张琪、顾锦法

7.穿孔素和颗粒酶B基因对肝移植急性排斥早期诊断的实验研究　中国人民解放军南京军区福州总医院、中国人民解放军第二军医大学第三附属医院　2004福建省科学技术进步二等奖，张绍庚、谈景旺、钱其军、杨甲梅、吴孟超

8.脾内转染白介素12及白介素2基因对肝癌的基因治疗上海市科学技术进步三等奖，2003年（排名第二）杨家和、钱其军、尤天庚、范瑞芳、苏长青、薛惠斌、李楠

发表文章

Wen W, Song S, Han Y, Chen H, Liu X, Qian Q. An efficient Screening System in Yeast to Select a Hyperactive piggyBac Transposase for Mammalian Applications. Int J Mol Sci. 2020;21(9):3064. Published 2020 Apr 26. doi:10.3390/ijms21093064Chen C, Aldarouish M, Li Q, Liu X, Han F, Liu H, Qian Q. Triggered Immune Response Induced by Antigenic Epitopes Covalently Linked with Immunoadjuvant-Pulsed Dendritic Cells as a Promising Cancer Vaccine. J Immunol Res. 2020;2020:3965061. Published 2020 Apr 4. doi:10.1155/2020/3965061Qiu J, Zhou F, Li X, Zhang S, Chen Z, Xu Z, Lu G, Zhu Z, Ding N, Lou J, Ye Z, Qian Q. Changes and Clinical Significance of Detailed Peripheral Lymphocyte Subsets in Evaluating the Immunity for Cancer Patients. Cancer Manag Res. 2020;12:209-219. Published 2020 Jan 9. doi:10.2147/CMAR.S221586Zhang M, Yang J, Hua W, Li Z, Xu Z, Qian Q. Monitoring checkpoint inhibitors: predictive biomarkers in immunotherapy. Front Med. 2019;13(1):32-44. doi:10.1007/s11684-018-0678-0Ye Z, Ding Y, Chen Z, Li Z, Ma S, Xu Z, Cheng L, Wang X, Zhang X, Ding N, Zhang Q, Qian Q. Detecting and phenotyping of aneuploid circulating tumor cells in patients with various malignancies. Cancer Biol Ther. 2019;20(4):546-551. doi:10.1080/15384047.2018.1538000Zhang Z, Jiang D, Yang H, He Z, Liu X, Qin W, Li L, Wang C, Li Y, Li H, Xu H, Jin H, Qian Q. Modified CAR T cells targeting membrane-proximal epitope of mesothelin enhances the antitumor function against large solid tumor [published correction appears in Cell Death Dis. 2020 Apr 16;11(4):235]. Cell Death Dis. 2019;10(7):476. Published 2019 Jun 17. doi:10.1038/s41419-019-1711-1Zhuang Y, Zhang C, Wu Q, Zhang J, Ye Z, Qian Q. Application of immune repertoire sequencing in cancer immunotherapy. Int Immunopharmacol. 2019;74:105688. doi:10.1016/j.intimp.2019.105688Wang P, Qin W, Liu T, Jiang D, Cui L, Liu X, Fang Y, Tang X, Jin H, Qian Q. PiggyBac-engineered T cells expressing a glypican-3-specific chimeric antigen receptor show potent activities against hepatocellular carcinoma. Immunobiology. 2020;225(1):151850. doi:10.1016/j.imbio.2019.09.009Huang Y, Lv SQ, Liu PY, Ye ZL, Yang H, Li LF, Zhu HL, Wang Y, Cui LZ, Jiang DQ, Hao FY, Xu HM, Jin HJ, Qian QJ. A SIRPα-Fc fusion protein enhances the antitumor effect of oncolytic adenovirus against ovarian cancer. Mol Oncol. 2020;14(3):657-668. doi:10.1002/1878-0261.12628Ye Z, Qian Q, Jin H, Qian Q. Cancer vaccine: learning lessons from immune checkpoint inhibitors. J Cancer. 2018;9(2):263-268. Published 2018 Jan 1. doi:10.7150/jca.20059Wang Y, Yang X, Yu Y, Xu Z, Sun Y, Liu H, Cheng J, Liu M, Sha B, Li L, Ding N, Li Z, Jin H, Qian Q. Immunotherapy of patient with hepatocellular carcinoma using cytotoxic T lymphocytes ex vivo activated with tumor antigen-pulsed dendritic cells. J Cancer. 2018;9(2):275-287. Published 2018 Jan 1. doi:10.7150/jca.22176Li H, Huang Y, Jiang DQ, Cui LZ, He Z, Wang C, Zhang ZW, Zhu HL, Ding YM, Li LF, Li Q, Jin HJ, Qian QJ. Antitumor activity of EGFR-specific CAR T cells against non-small-cell lung cancer cells in vitro and in mice. Cell Death Dis. 2018;9(2):177. Published 2018 Feb 7. doi:10.1038/s41419-017-0238-6He J, Zhang Z, Lv S, Liu X, Cui L, Jiang D, Zhang Q, Li L, Qin W, Jin H, Qian Q. Engineered CAR T cells targeting mesothelin by piggyBac transposon system for the treatment of pancreatic cancer. Cell Immunol. 2018;329:31-40. doi:10.1016/j.cellimm.2018.04.007Xu JY, Ye ZL, Jiang DQ, He JC, Ding YM, Li LF, Lv SQ, Wang Y, Jin HJ, Qian QJ. Mesothelin-targeting chimeric antigen receptor-modified T cells by piggyBac transposon system suppress the growth of bile duct carcinoma. Tumour Biol. 2017;39(4):1010428317695949. doi:10.1177/1010428317695949Wang Y, Ding M, Zhang Q, Wang J, Yang X, Zhou F, Li L, Yuan Z, Jin H, Qian Q. Activation or suppression of the immune response mediators in biliary tract cancer (BTC) patients: a systematic review and meta-analysis. J Cancer. 2017;8(1):74-84. Published 2017 Jan 1. doi:10.7150/jca.16774Lv SQ, Ye ZL, Liu PY, Huang Y, Li LF, Liu H, Zhu HL, Jin HJ, Qian QJ. 11R-P53 and GM-CSF Expressing Oncolytic Adenovirus Target Cancer Stem Cells with Enhanced Synergistic Activity. J Cancer. 2017;8(2):199-206. Published 2017 Jan 13. doi:10.7150/jca.16406Ye Z, Li Z, Jin H, Qian Q. Therapeutic Cancer Vaccines. Adv Exp Med Biol. 2016;909:139-167. doi:10.1007/978-94-017-7555-7_3Zhang H, Ye ZL, Yuan ZG, Luo ZQ, Jin HJ, Qian QJ. New Strategies for the Treatment of Solid Tumors with CAR-T Cells. Int J Biol Sci. 2016;12(6):718-729. Published 2016 Apr 28. doi:10.7150/ijbs.14405Ye Z, Jin H, Qian Q. Argonaute 2: A Novel Rising Star in Cancer Research. J Cancer. 2015;6(9):877-882. Published 2015 Jul 16. doi:10.7150/jca.11735Ye ZL, Huang Y, Li LF, Zhu HL, Gao HX, Liu H, Lv SQ, Xu ZH, Zheng LN, Liu T, Zhang JL, Jin HJ, Qian QJ. Argonaute 2 promotes angiogenesis via the PTEN/VEGF signaling pathway in human hepatocellular carcinoma [published correction appears in Acta Pharmacol Sin. 2018 Feb;39(2):329]. Acta Pharmacol Sin. 2015;36(10):1237-1245. doi:10.1038/aps.2015.18Wang Y, Xu Z, Zhou F, Sun Y, Chen J, Li L, Jin H, Qian Q. The combination of dendritic cells-cytotoxic T lymphocytes/cytokine-induced killer (DC-CTL/CIK) therapy exerts immune and clinical responses in patients with malignant tumors. Exp Hematol Oncol. 2015;4:32. Published 2015 Nov 10. doi:10.1186/s40164-015-0027-9Li J, Yu Y, Wang J, Yan Z, Liu H, Wang Y, Ding M, Cui L, Wu M, Jiang X, Qian Q. Establishment of a novel system for the culture and expansion of hepatic stem-like cancer cells. Cancer Lett. 2015;360(2):177-186. doi:10.1016/j.canlet.2015.02.006Ding M, LiJ, Yu Y, Liu H, Yan Z, Wang J,Qian Q. Integrated analysis of miRNA, gene, and pathwayregulatory networks in hepatic cancer stem cells.J Transl Med.2015;13:259. Published 2015 Aug 11. doi:10.1186/s12967-015-0609-7Zhang J, Jin H, Liu H, Lv S, Wang B, Wang R, Liu H, Ding M, Yang Y, Li L, Zhang J, Fu S, Xie D, Wu M, Zhou W, Qian Q. MiRNA-99a directly regulates AGO2 through translational repression in hepatocellular carcinoma. Oncogenesis. 2014;3(4):e97. Published 2014 Apr 14. doi:10.1038/oncsis.2014.11Peng X, Liu T, Shi C, Zhang L, Wang Y, Zhao W, Jiang L, Wu M, Zhang Y, Qian Q. Germline transmission of an embryonic stem cell line derived from BALB/c cataract mice. PLoS One. 2014;9(3):e90707. Published 2014 Mar 4. doi:10.1371/journal.pone.0090707Hong J, Jin H, Han J, Hu H, Liu J, Li L, Huang Y, Wang D, Wu M, Qiu L, Qian Q. Infusion of human umbilical cord derived mesenchymal stem cells effectively relieves liver cirrhosis in DEN induced rats. Mol Med Rep. 2014;9(4):1103-1111. doi:10.3892/mmr.2014.1927Tong Y, You L, Liu H, Li L, Meng H, Qian Q, Qian W. Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia. Oncotarget. 2013;4(6):860-874. doi:10.18632/oncotarget.1018Yan HX, Wu HP, Zhang HL, Ashton C, Tong C, Wu J, Qian QJ, Wang HY, Ying QL. DNA damage-induced sustained p53 activation contributes to inflammation-associated hepatocarcinogenesis in rats. Oncogene. 2013;32(38):4565-4571. doi:10.1038/onc.2012.451Yan HX, Wu HP, Zhang HL, Ashton C, Tong C, Wu H, Qian QJ, Wang HY, Ying QL. p53 promotes inflammation-associated hepatocarcinogenesis by inducing HMGB1 release. J Hepatol. 2013;59(4):762-768. doi:10.1016/j.jhep.2013.05.029Wang J, Yu Y, Yan Z, Hu Z, Li L, Li J, Jiang X, Qian Q. Anticancer activity of oncolytic adenoviruses carrying p53 is augmented by 11R in gallbladder cancer cell lines in vitro and in vivo. Oncol Rep. 2013;30(2):833-841. doi:10.3892/or.2013.2511Wang J, Li L, Zhang K, Yu Y, Li B, Li J, Yan Z, Hu Z, Yen Y, Wu M, Jiang X, Qian Q. Characterization of two novel cell lines with distinct heterogeneity derived from a single human bile duct carcinoma. PLoS One. 2013;8(1):e54377. doi:10.1371/journal.pone.0054377Peng X, Liu T, Yang B, Shi C, Sun Y, Jiang L, Jin H, Li L, Zhu H, Wu M, Qian Q. Germ-line-competent embryonic stem cells of the Chinese Kunming mouse strain with long-term self-renewal ability. Cell Reprogram. 2013;15(3):179-184. doi:10.1089/cell.2012.0065Peng X, Gao H, Wang Y, Yang B, Liu T, Sun Y, Jin H, Jiang L, Li L, Wu M, Qian Q. Conversion of rat embryonic stem cells into neural precursors in chemical-defined medium. Biochem Biophys Res Commun. 2013;431(4):783-787. doi:10.1016/j.bbrc.2013.01.023Li J, Liu H, Li L, Wu H, Wang C, Yan Z, Wang Y, Su C,Jin H, Zhou F, Wu M,Qian Q. Thecombination of an oxygen-dependent degradation domain-regulated adenovirusexpressing the chemokine RANTES/CCL5 and NK-92 cells exerts enhanced antitumoractivity in hepatocellular carcinoma.Oncol Rep.2013;29(3):895-902. doi:10.3892/or.2012.2217Wang JH, Li LF, Yu Y, Li B, Jin HJ, Shen DH, Li J,Jiang XQ,Qian QJ.Establishment and characterization of a cell line, EH-GB2, derived from hepaticmetastasis of gallbladder cancer.Oncol Rep. 2012;27(3):775-782.doi:10.3892/or.2011.1570Peng X, Liu T, Wang Y, Yan Q, Jin H, Li L, Qian Q, Wu M. Wnt/beta-catenin signaling in embryonic stem cell converted tumor cells. J Transl Med. 2012;10:196. Published 2012 Sep 20. doi:10.1186/1479-5876-10-196Liu XR, Cai Y, Cao X, Wei RC, Li HL, Zhou XM, Zhang KJ, Wu S, Qian QJ, Cheng B, Huang K, Liu XY. A new oncolytic adenoviral vector carrying dual tumour suppressor genes shows potent anti-tumour effect. J Cell Mol Med. 2012;16(6):1298-1309. doi:10.1111/j.1582-4934.2011.01396.xLiu T, Wang Y, Peng X, Zhang L, Cheng J, Jin H, Wu M, Qian Q. Establishment of mouse teratocarcinomas stem cells line and screening genes responsible for malignancy. PLoS One. 2012;7(8):e43955. doi:10.1371/journal.pone.0043955Wei RC, Cao X, Gui JH, Zhou XM, Zhong D, Yan QL, Huang WD, Qian QJ, Zhao FL, Liu XY. Augmenting the antitumor effect of TRAIL by SOCS3 with double-regulated replicating oncolytic adenovirus in hepatocellular carcinoma. Hum Gene Ther. 2011;22(9):1109-1119. doi:10.1089/hum.2010.219Liu X, Qian Q, Xu P, Wolf F, Zhang J, Zhang D, Li C, Huang Q. A novel conditionally replicating "armed" adenovirus selectively targeting gastrointestinal tumors with aberrant wnt signaling. Hum Gene Ther. 2011;22(4):427-437. doi:10.1089/hum.2010.128Jin H, Lv S, Yang J, Wang X, Hu H, Su C, Zhou C, Li J, Huang Y, Li L, Liu X, Wu M, Qian Q. Use of microRNA Let-7 to control the replication specificity of oncolytic adenovirus in hepatocellular carcinoma cells. PLoS One. 2011;6(7):e21307. doi:10.1371/journal.pone.0021307Ji W, Yang J, Wang D, Cao L, Tan W, Qian H, Sun B, Qian Q, Yin Z, Wu M, Su C. hSulf-1 gene exhibits anticancer efficacy through negatively regulating VEGFR-2 signaling in human cancers. PLoS One. 2011;6(8):e23274. doi:10.1371/journal.pone.0023274Hu H, Li Z, Chen J, Wang D, Ma J, Wang W, Li J, Wu H, Li L, Wu M, Qian Q, Chen J, Su C. P16 reactivation induces anoikis and exhibits antitumour potency by downregulating Akt/survivin signalling in hepatocellular carcinoma cells. Gut. 2011;60(5):710-721. doi:10.1136/gut.2010.220020He X, LiuJ, Yang C, Su C, Zhou C, Zhang Q, Li L, Wu H, Liu X, Wu M,Qian Q. 5/35fiber-modified conditionally replicative adenovirus armed with p53 showsincreased tumor-suppressing capacity to breast cancer cells.Hum GeneTher. 2011;22(3):283-292.doi:10.1089/hum.2010.058Chen W, Wu Y, Liu W, Wang G, Wang X, Yang Y, Chen W, Tai Y, Lu M, Qian Q, Zhang Q, Chen G. Enhanced antitumor efficacy of a novel fiber chimeric oncolytic adenovirus expressing p53 on hepatocellular carcinoma. Cancer Lett. 2011;307(1):93-103. doi:10.1016/j.canlet.2011.03.021Cao X, Yang M, Wei RC, Zeng Y, Gu JF, Huang WD, Yang DQ, Li HL, Ding M, Wei N, Zhang KJ, Xu B, Liu XR, Qian QJ, Liu XY. Cancer targeting Gene-Viro-Therapy of liver carcinoma by dual-regulated oncolytic adenovirus armed with TRAIL gene. Gene Ther. 2011;18(8):765-777. doi:10.1038/gt.2011.16Yu DB, Zhong SY, Yang M, Wang YG, Qian QJ, Zheng S, Liu XY. Potent antitumor activity of double-regulated oncolytic adenovirus-mediated ST13 for colorectal cancer. Cancer Sci. 2009;100(4):678-683. doi:10.1111/j.1349-7006.2009.01110.xYao Y, Jia XY, Tian HY, Jiang YX, Xu GJ,Qian QJ, Zhao FK.Comparative proteomic analysis of colon cancer cells in response to oxaliplatintreatment.Biochim Biophys Acta. 2009;1794(10):1433-1440.doi:10.1016/j.bbapap.2009.06.005Xu Z, Jin H, Qian Q. Humanized anti-EphB4 antibodies for the treatment of carcinomas and vasculogenesis-related diseases. Expert Opin Ther Pat. 2009;19(7):1035-1037. doi:10.1517/13543770902835525Xie M, Niu JH, Chang Y, Qian QJ, Wu HP, Li LF, Zhang Y, Li JL, Huang XJ, Ruan GR. A novel triple-regulated oncolytic adenovirus carrying PDCD5 gene exerts potent antitumor efficacy on common human leukemic cell lines. Apoptosis. 2009;14(9):1086-1094. doi:10.1007/s10495-009-0373-3Wang G, Li G, Liu H, Yang C, Yang X, Jin J, Liu X, Qian Q, Qian W. E1B 55-kDa deleted, Ad5/F35 fiber chimeric adenovirus, a potential oncolytic agent for B-lymphocytic malignancies. J Gene Med. 2009;11(6):477-485. doi:10.1002/jgm.1326Rebetz J, Na M, Su C, Holmqvist B, Edqvist A, Nyberg C, Widegren B, Salford LG, Sj?gren HO, Arnberg N, Qian Q, Fan X. Fiber mediated receptor masking in non-infected bystander cells restricts adenovirus cell killing effect but promotes adenovirus host co-existence. PLoS One. 2009;4(12):e8484. Published 2009 Dec 29. doi:10.1371/journal.pone.0008484Jin J, Liu H, Yang C, Li G, Liu X, Qian Q, Qian W. Effective gene-viral therapy of leukemia by a new fiber chimeric oncolytic adenovirus expressing TRAIL: in vitro and in vivo evaluation. Mol Cancer Ther. 2009;8(5):1387-1397. doi:10.1158/1535-7163.MCT-08-0962Guo M, Kang B, Zheng Q, Qian Q, Su C, Wu M, Yang J. An anti-preS2 antibody protects human hepatocytes from hepatitis B virus infection. Acta Gastroenterol Belg. 2009;72(3):306-311.Xu, Z., Zhou, X., Shi, Qian Q. 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