郭德银的个人简介
郭德银，1965年4月于河南省夏邑县， 国家杰出青年基金获得者，国家“973”重大科学研究计划项目首席科学家，国家基金委创新研究群体骨干成员。现任中山大学医学院院长，教授、博导，国家杰出青年基金获得者，国家“973”计划首席科学家，中国微生物学会病毒学专业委员会主委，国家创新人才推进计划重点领域创新团队负责人。学科专业：微生物学/病毒学、病原生物学、分子生物学。曾任武汉大学基础医学院院长，武汉大学生命科学学院副院长，武汉大学生命科学学院教授，病毒学国家重点实验室副主任，武汉大学现代病毒学研究中心负责人。2001年6月提升为赫尔辛基大学生物系副教授。从2002年9月起受聘武汉大学生命科学学院病毒学科特聘教授 任基础医学院院长。2016-2020 任中山大学基础医学院（深圳）院长研究RNA病毒（冠状病毒和丙肝病毒）的基因组复制和与宿主细胞相互作用的分子机理。
个人经历
2011-迄今武汉大学基础医学院教授、院长，医学研究院PI、副院长
2002-迄今 武汉大学生命科学学院教授，现代病毒学研究中心执行主任，副院长（2004-2011），
1996-2002 芬兰赫尔辛基大学生物技术研究所 博士后，生物科学系docent（2001）
1991-1995 德国布伦瑞克理工大学生物系博士生，联邦生物化学与植物病毒研究生研究助理
1990-1991 同济大学留德预备部 德语学习
1985-1988 中国农业科学院研究生院、中国科学院微生物研究所 硕士研究生
2016-2020 中山大学基础医学院（深圳）院长
学术兼职
中国微生物学会病毒专业委员会委员（2004-）
国家高等级病原微生物生物安全审查委员会委员 (2009-)
国家认可委实验室生物安全专业委员会委员（2012-）
病毒学国家重点实验室副主任（2005-）
中国细胞生物学会细胞免疫分会理事
湖北省微生物学会常务理事/医学微生物专业委员会主任
个人荣誉
国家杰出青年基金获得者（2009）
国家“973”计划首席科学家（2009）
中国微生物学会病毒专业委员会梅里埃奖（2010）
武汉大学十大杰出青年教师（2004）
武汉大学十大师德标兵（2010）
武汉大学朱裕壁医学奖（2011）
湖北省劳动模范（2004）
国务院特殊津贴专家
研究领域
RNA病毒（冠状病毒和丙肝病毒）的基因组复制和与宿主细胞相互作用的分子机理；病毒免疫逃逸的分子机制；基于RNA干扰（RNAi）的艾滋病毒基因治疗。
论文发表
近期代表性论文：（总共发表SCI论文83篇）
Dan Liu, Lei Cui, Yuan Wang, Guifang Yang, Ruidong Hao, Jing He, Chengpeng Fan, Mengmeng Qu, Zhepeng Liu, Min Wang, Lang Chen and Deyin Guo* (2016) HBV e antigen and its precursors promote the progress of hepatocellular carcinoma by interacting with NUMB and decreasing p53 stability and activity. Hepatology 64, 390-404. 2016 Apr 22. doi: 10.1002/hep.28594. [Epub ahead of print]Shun Li, Mingzhu Zhu, Ruangang Pan, Ting Fang, Yuan-Yuan Cao, Shuliang Chen, Xiaolu Zhao, Cao-Qi Lei, Lin Guo, Yu Chen, Chunmei Li, Eija Jokitalo, Yuxin Yin, Hong-Bing Shu, Deyin Guo* (2016) The tumor suppressor PTEN has a critical role in antiviral innate immunity. Nature Immunology 17, 241-249. (Advance Online Publication on Dec. 21, 2015; With expert comment in the News & Views section of the same issue)Yu Chen, Hui Cai, Jiu2019an Pan, Nian Xiang, Po Tien, Tero Ahola, Deyin Guo* (2009) Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase. Proceedings of the National Academy of Sciences of the United States of America 106, 3484-9.Yu Chen, Ceyang Su, Min Ke, Xu Jin, Lirong Xu, Zhou Zhang, Andong Wu, Ying Sun, Zhouning Yang, Po Tien, Tero Ahola, Yi Liang, Xinqi Liu, Deyin Guo* (2011) Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2’-O-methylation by nsp16/nsp10 protein complex. PLoS Pathogens 7(10): e1002294. doi:10.1371/journal.ppat.1002294.Yi Wang, Ying Sun, Andong Wu, Shan Xu, Ruangang Pan, Cong Zeng, Xu Jin, Xingyi Ge, Zhengli Shi, Tero Ahola, Yu Chen*, Deyin Guo* (2015) Coronavirus nsp10/nsp16 methyltransferase can be targeted by nsp10-derived peptide in vitro and in vivo to reduce replication and pathogenesis. Journal of Virology 89, 8416-27.Cong Zeng, Andong Wu, Yi Wang, Shan Xu, Yingke Tang, Xu Jin, Shilei Wang, Lei Qin, Ying Sun, Chengpeng Fan, Eric J. Snijder, Benjamin W. Neuman, Yu Chen,Tero Ahola and Deyin Guo* (2016) Identification and Characterization of a Ribose 2’-O-Methyltransferase Encoded by the Ronivirus Branch of Nidovirales. Journal of Virology 90(15):6675-85.Lei Cui, Haiying Wang, Yanxi Ji, Jie Yang, Shan Xu, Xingyu Huang, Zidao Wang, Lei Qin, Po Tien, Xi Zhou, Deyin Guo*, Yu Chen* (2015) The nucleocapsid protein of coronaviruses acts as a viral suppressor of RNA silencing in mammalian cells. Journal of Virology 89, 9029-43.Yu Chen, Jiali Tao, Ying Sun, Andong Wu, Ceyang Su, Guozhen Gao, Hui Cai, Su Qiu, Yingliang Wu, Tero Ahola, Deyin Guo* (2013) Structure-function analysis of SARS coronavirus RNA cap guanine-N7 methyltransferase. Journal of Virology 87, 6296-305.Mingzhu Zhu, Ting Fang, Shun Li, Kun Meng, Deyin Guo* (2015) Bipartite nuclear localization signal controls nuclear import and DNA binding activity of interferon regulatory factor 3. Journal of Immunology 195, 289-97.Ruidong Hao, Jing He, Xing Liu, Guozhen Gao, Dan Liu, Lei Cui, Guojun Yu, Wenhui Yu, Yu Chen, Deyin Guo* (2015) Inhibition of hepatitis B virus gene expression and replication by hepatocyte nuclear factor 6. Journal of Virology 89, 4345-55.Panpan Hou, Shuliang Chen, Shilei Wang, Xiao Yu, Yu Chen, Meng Jiang, Ke Zhuang, Wenzhe Ho, Wei Hou, Jian Huang and Deyin Guo* (2015). Genome editing of CXCR4 by CRISPR/cas9 confers cells resistance to HIV-1 infection. Scientific Reports 2015 Oct 20;5:15577. doi: 10.1038/srep15577.Miao Jiang, Pamela ?sterlund, Peter Sarin, Minna Poranen, Dennis Bamford, Deyin Guo* and Ilkka Julkunen* (2011) Innate immune responses in human monocyte-derived dendritic cells are highly dependent on the size and the 5’-phosphorylation of RNA molecules. Journal of Immunology 187, 1713-21.13. Yu Chen, Hui Cai, Jiu2019an Pan, Nian Xiang, Po Tien, Tero Ahola, Deyin Guo (2009). Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase. Proceedings of the National Academy of Sciences of the United States of America 106, 3484-9.
14. Junwei Li, Musarat Ishaq, Mabiala Prudence, Xiao Xi, Tao Hu, Qingzhen Liu, Deyin Guo (2009) Single mutation at the amino acid position 627 of PB2 that leads to increased virulence of an H5N1 avian influenza virus during adaptation in mice can be compensated by multiple mutations at other sites of PB2. Virus Research 144, 123-9.
15. Tao Hu, Qiong Fu, Ping Chen, Li Ma, Onsam Sin and Deyin Guo (2009) Construction of an Artificial MicroRNA Expression Vector for Simultaneous Inhibition of Multiple Genes in Mammalian Cells. International Journal of Molecular Sciences 10, 2158-2168.
16. Yaling Yang, Snawar Hussain, Hao Wang, Min Ke, Deyin Guo (2009) Translational control of the subgenomic RNAs of severe acute respiratory syndrome coronavirus. Virus Genes 39, 10-18.
17. Ping Chen, Tao Hu, Miao Jiang, Deyin Guo. (2009). Synthesis in E. coli cells and characterization of the active exoribonuclease of severe acute respiratory syndrome coronavirus. Molecular Biology 3, 410-417.
18. Ke Zhang, Yu Chen, Jiu2019an Pan, Tero Ahola, Deyin Guo (2009) Lentiviral vector-derived shRNAs confer enhanced suppression of Semliki forest virus replication in BHK-21 cells compared to shRNAs expressed from plasmids. Biotechnology Letters 31, 501-508.
19. Tao Hu, Qiong Fu, Ping Chen, Ke Zhang, Deyin Guo (2009) Generation of a stable mammalian cell line for simultaneous expression of multiple genes by using 2A peptide-based lentiviral vector. Biotechnology Letters 31, 353-359.
20. Musarat Ishaq, Li Ma, Xiaoyun Wu, Yongxin Mu, Jiu2019an Pan, Jiajie Hu, Tao Hu, Qiong Fu and Deyin Guo (2009). The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription. Journal of Cellular Biochemistry 106, 296-305.
21. Xiaoyun Wu, You Zhou, Ke Zhang, Qingzhen Liu & Deyin Guo (2008). Isoform-specific interaction of pyruvate kinase with hepatitis C virus NS5B. FEBS Letters 582, 2155-2160.
22. Jiu2019An Pan, Xiaoxue Peng, Yajing Gao, Zhilin Li, Xiaolu Lu, Yingzhao Chen, Musarat Ishaq, Dan Liu, Marta L. DeDiego, Luis Enjuanes and Deyin Guo. (2008). Genome-wide analysis of protein-protein interactions and involvement of viral proteins in SARS-CoV replication. PLoS ONE 3, e3299.
23. Xiaoyun Wu, Musarat Ishaq, Jiajie Hu, Deyin Guo (2008). HCV NS3/4A protein activates HIV-1 transcription from its long terminal repeat. Virus Research 135, 155-160.
24. Musarat Ishaq, Jiajie Hu, Xiaoyun Wu, Qingzhen Liu and Deyin Guo. (2008). Knockdown of cellular RNA helicase DDX3 by short hairpin RNAs suppresses HIV-1 viral replication without inducing apoptosis. Molecular Biotechnology 39, 231-238.
25. Yaling Yang, Quan Wang, Deyin Guo (2008). A Novel Strategy for Analyzing RNA-Protein Interactions by Surface Plasmon Resonance Biosensor. Molecular Biotechnology 40, 87-93.
26. Junwei Li, Hui Cai, Qingzhen Liu & Deyin Guo (2008). Molecular and pathological characterization of two H5N1 avian influenza viruses isolated from wild ducks. Virus Genes 37, 88-95.
27. Deyin Guo, Minna-Leena Rajam?ki & Jari Valkonen. (2008). Protein-protein interactions: the yeast two-hybrid system. Methods in Molecular Biology 451, 421-439.
28. Zuoxiang Xiao, Yong Xiong, Lindi Tan, Elana Ehrlich, Deyin Guo and Xiao-Fang Yu (2007). Characterization of a Novel Cullin5 Binding Domain in HIV-1 Vif. Journal of Molecular Biology 373, 541-550.
29. Ping Chen, Miao Jiang, Tao Hu, Qingzhen Liu, Xiaojiang S. Chen, Deyin Guo (2007) Biochemical characterization of exoribonuclease encoded by SARS coronavirus. Journal of Biochemistry & Molecular Biology 40, 649-655.
30. Xiaoxue Peng, Jiu2019an Pan, Rui Gong, Yang Liu, Shuli Kang, Huixing Feng, Gang Qiu, Deyin Guo, Po Tien, and Gengfu Xiao. (2007). Functional characterization of syncytin-A, a newly murine endogenous virus envelope protein: implication for its fusion mechanism. Journal of Biological Chemistry 282, 381-9.
31. Zhaoyang Li, Yong Xiong, Yu Peng, Jiu2019an Pan, Yu Chen, Xiaoyun Wu, Snawar Hussain, Po Tien, Deyin Guo. (2005). Specific inhibition of HIV-1 replication by short hairpin RNAs targeting human cyclin T1 without inducing apoptosis. FEBS Letters 579, 3100-6.
32. Snawar Hussain, Jiu2019an Pan, Yu Chen, Yalin Yang, Jing Xu, Yu Peng, Ying Wu, Zhaoyang Li, Ying Zhu, Po Tien, Deyin Guo. (2005). Identification of novel subgenomic RNAs and noncanonical transcription initiation signals of severe acute respiratory syndrome coronavirus. Journal of Virology 79, 5288-95.
