侯亚义的个人简介
侯亚义，获南京大学理学学士和硕士学位、日本东京大学博士学位。曾在东京大学从事博士后研究和作为访问教授在美国密西根大学医学院进行合作科研。曾主持南京大学"985工程"一期免疫生物学学科建设和参与“985”二期“公共健康医学”科研平台的筹划和建设。
个人成就
侯亚义，男，博士、教授、博士生导师，江苏省免疫学会常务理事。现主要从事细胞与分子免疫学研究，主要聚焦于自身免疫性疾病中免疫细胞功能和信号传导的调控以及肿瘤的分子免疫机制与治疗等。曾主持国家自然科学基金、教育部科学技术重点基金及横向科研等项目，参与江苏省卫生厅科学基金等项目。现主持国家自然科学基金、江苏省自然科学基金及江苏省卫生厅重大科学基金，参与国家科技重大专项项目、“973计划”、国家自然科学基金委重大研究计划、江苏省卫生厅“兴卫工程”基金及江苏省科学技术厅高技术研究（医药）重大项目等项目。江苏省“六大人才高峰”第五批高层次人才。2005年参编专著1部(科学出版社)。已发表国内外论文106篇，其中SCI论文49篇。申请专利3项。
代表性著作
1. Mesenchymal Stem Cell Transplantation Reverses Multi-Organ Dysfunction in Systemic Lupus Erythematosus Mice and Humans. Stem cell. 2009.
2. Changes in NK Cell Counts and Receptor Expressions and Emergence of CD3dimCD56+ Cells in HIV-1 Infected Patients in China. Viral Immunology, 22(2):1-12, 2009.
3. 17β-Estradiol Suppresses Cytotoxicity and Proliferative Capacity of Murine Splenic NK1.1+ Cells. Cell & Mol Immunology. 2008;5(5):357-364.
4. Transdifferentiation of mesenchymal stem cells derived-from human fetal lung to hepatocyte-like cells. Cell Biology Int, 2008, 32:1091-1098.
5. Protein expression and purification of human Zbtb7A in Pichia pastoris via gene codon optimization and synthesis. Protein Expression and Purification, 2008, 60: 97-102.
6. Estrogen modulates bone marrow-derived DCs in SLE murine model-(NZB x NZW) F1 female mice. Immunol Invest,2008, 37(3):227-43.
7. Over-expressed and truncated midkines promote proliferation of BGC823 cells in vitro and tumor growth in vivo. WJG, 2008, 14(12): 1858-1865.
8. Lung Cancer Risk Associated with Thr495Pro Polymorphism of GHR in Chinese Population. Jpn J Clin Oncol 2008; 38(4)308u2013316.
9. Estrogen distinctively modulates spleen DC from (NZB ? NZW) F1 female mice in various disease development stages. Cell Immunology, 2007, 248: 95u2013102
10. siRNA targeting midkine inhibits gastric cancer cells growth and induces apoptosis involved caspase-3,8,9 activation and mitochondrial depolarization. J Biomed Science, 2007, 14(6):783-95.
11. Modulation of 17beta-estradiol on the number and cytotoxicity of NK cells in vivo related to MCM and activating receptors. Int Immunopharmacol. 2007, 7(13):1765-75.
12. Changes in the Ratio of Tc1/Tc2 and h1/Th2 Cells but Not in Subtypes of NK-Cells in Preeclampsia. Int. J. Mol. Sci. 2007, 8, 492-504
13. Polarization of T Lymphocytes Is Regulated by Mesenchymal Stem Cells in NZBWF1 and BALB/c Mice. Int. J. Mol. Sci. 2007, 8, 455-469
14. Abnormal surface markers expression on bone marrow CD34+ cells and correlation with disease activity in patients with systemic lupus erythematosus. Clin Rheumatol, 2007, 26(12):2073-9
15. Abnormality of bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus. Lupus, 2007, 16 (2): 121-128
16. The Expression and Location of Midkine in Gastric Carcinomas of Chinese Patients. Cell & Mol Immunology. 2007, 4(2):135-140.
17. Different characters of spleen OX-62-positive dendritic cells between Fischer and Lewis rat. Cell & Mol Immunology, 2006, 3(2): 145-150.
18. Liposomal plasmid DNA encoding human thymosin α1 and interferon ω1 potently inhibits liver tumor growth in ICR mice. J Gastroenterol and Hepatol. 2006, 21: 1538u20131543
19. Progesterone is involved in the maturation of murine spleen CD11c-positive dendritic cells. Steroids, 2006, 71: 922u2013929.
20. Prolactin regulates phenotype, functions and cytokine expression of mouse spleen dendritic cells. Int Immunopharmacol. 2006, 6:1478-1486.
21. Progesterone Regulates Mouse Dendritic Cells Differentiation and Maturation. Int Immunopharmacol, 2006, 6: 830-838.
22. Effects of 17β-estrodial on the maturation, nuclear factor kappa B and functions of murine spleen CD11c positive dendritic cells. Mol Immunology, 43(4):357-366, 2006.
23. Nonylphenol-induced thymocyte apoptosis involved caspase-3 activation and mitochondrial depolarization. Mol Immunology, 2006 ，43：915-926.
科研项目
雌激素通过MCM6调控树突状细胞功能及其TLR9信号转导的机制研究。国家自然科学基金资助项目（30771959）。2008.1-2010.12。
新型抗癌药物SapC-DOPS的开发研究。江苏省科学技术厅高技术研究（医药）重大项目（BG2007604）。2007.03-2010.2。
从母胎界面免疫调节异常探索妊高症的预测方法。江苏省卫生厅科技项目（H200754 ）。2007.10-2010.9。
高危妊娠患者母胎界面免疫学的研究（XK200709）。江苏省卫生厅“兴卫工程”基金。2007-2012。
调控Toll样受体的新共生菌产物研究。国家自然科学基金委重大研究计划（90813036）。2009.1-2012.12。
艾滋病生物预防技术研究与产品研制。国家科技重大专项项目（2008ZX10001-015）。2008-2010。
获奖情况
2002年曾获南京市科技进步三等奖1项；
2005年度教育部提名国家科学技术奖受奖项目(科技进步奖二等)1项；
2007年度江苏省科技进步奖三等奖1项。
